U-500 Insulin: Clinical Comments From the Experts

U-500 Regular Insulin

OBJECTIVE To describe the clinical experience and the pharmacokinetics of U-500 regular insulin in severely insulin-resistant obese type 2 diabetic patients. RESEARCH DESIGN AND METHODS Patients requiring >200 units of insulin with A1C levels >8.0% were switched to U-500 regular insulin. For the pharmacokinetic study, fasting subjects received 100 units of U-500 regular insulin subcutaneously...

Clinical experience with U-500 regular insulin in obese, markedly insulin-resistant type 2 diabetic patients.

On a clinical basis, severe insulin resistance is defined as a situation in which a patient requires 200 units of insulin daily for 2 days (1). This definition was determined 50 years ago, when it was erroneously believed that the human pancreas secreted 200 units of insulin a day. Although it is now known that the normal pancreas secretes only 20–40 units of insulin a day, this clinical defini...

Stability of U-500 regular insulin in prefilled syringes.

OBJECTIVE To evaluate the stability of U-500 regular insulin in prefilled syringes stored under refrigeration for up to 28 days. METHODS U-500 regular insulin was drawn up in 1 mL insulin syringes in a clean, nonsterile environment to emulate conditions of a patient's home. Samples were assayed using a stability-indicating reverse-phase high-performance liquid chromatography method immediatel...

Clinical use of U-500 regular insulin: review and meta-analysis.

The use of U-500 regular insulin (U-500R) to treat diabetic patients with severe insulin resistance has increased. In this review, we performed a meta-analysis of PubMed studies reporting the use of U-500R to evaluate the effects of U-500R on hemoglobin A1c (HbA1c), body weight, and total daily insulin dose (TDD). These studies included 310 patients using U-500R as multiple daily injections (MD...

Use of U-500 Insulin in the Treatment of Severe Insulin Resistance